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Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. 2007 May; 132(6):2272-5. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 2003 Feb; 124(2):445-58. 1996 Dec 15; 98(12):2771-8. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 2007 Jun; 132(7):2601-4. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. J Gastroenterol Hepatol. 2015 Feb; 21(2):159-65. 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Hepatology. 2006 Aug; 116(8):2058-9. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. 1997 Nov; 113(5):1589-98. Am J Clin Nutr. 2005 Sep 16; 335(1):87-96. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Hepatology. Molecular and cellular biology of the small intestine. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. 2010 Feb; 16(2):181-90. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 2005 Jan; 54(1):134-41. Techniques to measure nucleic acid-protein binding and specificity. 2014 Jul; 124(7):2921-34. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. 2010 Feb 25; 3:39-47. Biochem Biophys Res Commun. J Biol Chem. Nucleic Acids Res. Signal transduction during liver regeneration. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. 2003 Apr; 37(4):833-41. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. Gut. 2005 Sep-Oct; 7(9-10):1346-55. Clin Gastroenterol Hepatol. Nat Commun. Adv Second Messenger Phosphoprotein Res. 2017 Apr 03; 127(4):1254-1270. 1995 Feb; 95(2):803-10. 1994 Jun 21; 91(13):6030-4. Nat Commun. 2010 Mar; 51(3):942-52. Alzheimer's disease: the vascular connection. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Gastroenterology. Therapeutic strategies for hepatic fibrosis. 2013 Mar; 62(3):335-6. J Cardiovasc Med (Hagerstown). J Biol Chem. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 1990; 14(6):639-45. 2020 11 03; 32(5):878-888.e6. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Cancer Res. Cell Cycle. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. 1994 Sep; 14 (9):5950-60. 2006 Jul 27; 82(2):241-50. Nuclear factor-kappaB in the liver: friend or foe? Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. 2005 Mar; 39(3):181-8. New Developments on the Treatment of Liver Fibrosis. 2010 Jan 12; 107(2):844-9. Next-generation academic medicine. J Hepatol. Allergy. New functions for the aryl hydrocarbon receptor. Dig Dis. 2018 01; 53(1):6-17. Role of Gut Microbiota in Liver Disease. 2020 12 15; 95(24):e3163-e3179. 2009 Jan; 49(1):6-8. 2018 12; 15(12):785. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2007 Dec 07; 249(3):518-31. J Clin Invest. Nat Rev Gastroenterol Hepatol. 2019 Apr 07; 20(7). 2012 Jun 12; 109(24):9448-53. Liver: DNA methylation controls liver fibrogenesis. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. J Biol Chem. 2005 Apr; 115(4):849-59. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2015 Nov-Dec; 49 Suppl 1:S69-73. Signal transduction during liver regeneration. Cancer Res. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. 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Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. See more options in the Advanced Search tab. J Clin Invest. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. The role of Smad3 in mediating mouse hepatic stellate cell activation. Brain. 2007 May; 132(5):1937-46. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Says David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune intersection with the microbiome effective 14. Usc undermined our ability to do research, says David Brenner, UCSDs chancellor! 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